Sequence analysis of the haemagglutinin of A/Taiwan/1/86, a new variant of human influenza A(H1N1) virus.
نویسنده
چکیده
A/Taiwan/1/86 is representative of newly emerged antigenic variants of influenza A(H1N1) viruses which are readily distinguishable from all previous A(H1N1) isolates. Nucleotide sequence analysis of the haemagglutinin HA1 coding region of A/Taiwan/1/86 suggests that this virus has evolved from viruses circulating in the Hong Kong region in 1982 to 1983. The considerable alteration in antigenicity of this new isolate is likely to have arisen from five amino acid substitutions in a nine amino acid stretch, situated on the outer surface of a short alpha-helix on the tip of the HA molecule in antigenic site Sb.
منابع مشابه
Antigenic Variation of the Haemagglutinin Gene of the Influenza A (H1N1) pdm09 Virus Circulating in Shiraz, February-April 2013
Background: A new pandemic influenza A (H1N1) emerged in April 2009, causing considerable morbidity and mortality. Since mutations in the haemagglutinin (HA) may influence the antigenicity and pathogenicity of the virus, continued epidemiological and molecular characterization for the effective control of pandemic flu and developing of more appropriate vaccine is crucial. Objective: To monitor ...
متن کاملDevelopment and Sequence Analysis of a Cold-Adapted Strain of Influenza A/New Caledonia/20/1999(H1N1) Virus
Background and Aims: Vaccination is the most effective method to prevent influenza infection. Among the available vaccines, cold-adapted live-virus vaccines are suitable approach that have been produced and evaluated for recent years in few countries. The goal of this project was to derivate a cold adapted variant of the influenza A/New Caledonia/20/1999(H1N1). Materials and Methods: Influenza ...
متن کاملMolecular Characterization and Phylogenetic Analysis of Neuraminidase Gene in A/H1N1 Influenza Virus Isolates Circulating in Iran, 2014-2015.
Objectives: Influenza is one of the most important emerging and reemerging infectious diseases in the world. The aim of this study is molecular and phylogenetic analyses of the variations in circulating influenza A/H1N1 virus isolates during 2014-2015 in Iran and investigate on the drug resistance conditions in the related Iranian isolates. Material and Methods: Throat samples from Iranian pat...
متن کاملBaculoviral Expression of Influenza A Virus (H1N1 New Caledonia) Neuraminidase in Insect Cells
Background and Aims: Each year, the influenza virus causes moderate to severe infections with a high prevalence throughout the world. Accordingly, an influenza vaccine that ensures protection with only a single dose would be a much more cost effective approach to influenza prophylaxis. Generation of Influenza non-replicating virus-like particles (VLP) in baculoviral expression system is an attr...
متن کاملPathogenicity and haemagglutinin gene sequence analysis of Iranian avian influenza H9N2 viruses isolated during (1998–2001)
Sixteen avian influenza (AI) H9N2 viruses were isolated from disease outbreaks in different parts of Iranduring (1998–2001). These AI isolates were used for pathogenicity, haemagglutinin (HA) gene variation andphylogenetic analysis. Results in both pathogenicity tests and HA gene cleavage site sequence detectionrepresented a non-highly pathogenic feature for all Iranian AI isolates studied. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of general virology
دوره 68 ( Pt 4) شماره
صفحات -
تاریخ انتشار 1987